Nathan "Nate" Drake wielding the .45 Defender.
|Appearances|| Uncharted 2: Among Thieves|
Uncharted 3: Drake's Deception
Uncharted: Golden Abyss
|Maximum ammo||64 rounds|
|Magazine capacity||8 rounds|
The .45 Defender first appears in Uncharted 2: Among Thieves, and throughout the series, it is shown to be wielded often by Australian explorer Chloe Frazer. The weapon returns in Uncharted 3: Drake's Deception and the PlayStation Vita video game Uncharted: Golden Abyss, in which it is primarily wielded by Roberto Guerro's men. The .45 Defender has a slow rate of fire but is very accurate.
 Behind the scenes
The .45 Defender is based on the real-life Colt .45 Defender.